This month I will be researching bioreactors, a device or system designed to support and control biological processes by providing a controlled environment with specific conditions. The article, Design and Construction of a Low-Cost compressive Loading and Perfusion Flow Bioreactor, highlights the bioreactor's functionality, design, flow system, and data acquisition.
Here is what I learned
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The bioreactor integrates perfusion flow and dynamic compressive loading to enhance cell culture and mechanical stimulation in 3D porous scaffolds
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The loading frame supports up to three chambers, fits standard CO2 incubators, and is constructed from commonly available bioinert, autoclavable materials for easy adaptation to user-specific applications.
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Media perfusion is achieved using a peristaltic pump and silicone tubing, enabling continuous nutrient transport, waste removal, and uniform cell seeding, with through-sample perfusion for enhanced shear stress distribution and nutrient delivery.
Thank you for tuning in and I'll see you next month!
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